Project snapshot: Can iso-PGs indicate the need for surgery and predict survival in colic horses?

This project examines how oxidative stress markers can improve outcomes for equine colic, a leading cause of death and economic loss in Australia’s $1.16 billion thoroughbred breeding industry.

About 4% of horses develop colic each year. Veterinarians often struggle to decide if surgery is needed. Delays can cause severe intestinal damage or lead to euthanasia. Early treatment improves survival. Current diagnostic tools lack consistency, so better and more objective indicators are needed.

The study focuses on isoprostanes in peritoneal fluid as early markers of gut or uterine ischaemia. Researchers analysed 300 samples from veterinary hospitals in Australia and the United States using LC–mass spectrometry.

Results show that specific isoprostanes, such as 5‑F2t‑IsoP and Isofurane, increase as disease severity rises. Levels also differ between horses treated medically and those needing surgery.

The study did not define clear cut-off values, but the results support isoprostanes as useful markers. They can help guide treatment decisions.

This research supports the development of a simple point-of-care test to help veterinarians act sooner, improve horse welfare and strengthen industry outcomes.

Read the full report here.