Recurrent laryngeal neuropathy (RLN) or “roaring”, is an important cause of upper airway disease in large breed performance horses, particularly Thoroughbreds, Warmbloods and Draft breeds. In simple terms, this disease can be described as paralysis of one side of the larynx, almost invariably the left. The cause and development of the condition are not completely understood.
This disease impairs ability of the horse to perform strenuous exercise. The condition therefore has serious health and economic consequences for patient and owner respectively.
The aim of this study was to expand our understanding of the changes that occur at a cellular and molecular level, in order to determine the regenerative potential of affected laryngeal muscle and the feasibility of studying the use of Neurotrophins to achieve more rapid and reliable laryngeal reinnervation in horses.