Early pregnancy in the mare: mechanisms of immune recognition and novel assays for pregnancy testing

The University of Newcastle

  • Project code: PRO-017254

  • Project stage: Current

  • Project start date: Friday, May 31, 2024

  • Project completion date: Thursday, September 30, 2027

  • National Priority: HOR-Thoroughbred breeding


of early pregnancy and limited understanding of the causes of early pregnancy
loss continue to impact the efficiency of thoroughbred breeding. This project
builds on preliminary data generated under PRJ-011748 – Developing a novel
diagnostic test for early pregnancy in the mare, where the project team
discovered several blood plasma biomarkers for early pregnancy in the mare, to
further develop these markers into practical assays and integrate these assays
with cutting-edge fluorescent nanoparticle technology to enhance sensitivity,
facilitate rapid detection and develop prototype devices.


Thoroughbred Horses

Research Organisation

The University of Newcastle

Objective Summary

1.Develop a set of
lab assays to measure blood markers of early pregnancy identified in our
previous study

2.Establish cut-off
values for detecting pregnancy using these assays

3.Combine these
assays with new detection technologies, to develop a prototype device for
pregnancy detection

4.Map the changes in
mare immune system function that are related to early pregnancy