Penetration of pharmacological agents through equine skin

The University of Queensland

  • Project code: PRJ-000534

  • Project stage: Closed

  • Project start date: Sunday, August 1, 2004

  • Project completion date: Monday, May 7, 2007

  • National Priority: HOR-Thoroughbred diseases and parasites


Thoroughbred Horses

Research Organisation

The University of Queensland

Objective Summary

. To develop in vitro and in vivo methodologies to measure drug movement through equine skin . To measure the regional differences (eg neck vs back vs axilla vs lower leg) in drug penetration . To measure transdermal penetration of drugs of interest to the equine industry including non-steroidal anti-inflammatory drugs (NSAIDs) corticosteroids and analgesics (eg Fentary) . To determine the effects of vehicles (eg DMSO) on penetration of drugs in the horse . To determine the effects of skin damage (eg rashes) and altered microenvironment (eg bandages saddles) on transdermal drug movement in the horse