Penetration of pharmacological agents through equine skin
The University of Queensland
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Project code: PRJ-000534
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Project stage: Closed
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Project start date: Sunday, August 1, 2004
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Project completion date: Monday, May 7, 2007
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National Priority: HOR-Thoroughbred diseases and parasites
Program
Thoroughbred Horses
Research Organisation
The University of Queensland
Objective Summary
. To develop in vitro and in vivo methodologies to measure drug movement through equine skin . To measure the regional differences (eg neck vs back vs axilla vs lower leg) in drug penetration . To measure transdermal penetration of drugs of interest to the equine industry including non-steroidal anti-inflammatory drugs (NSAIDs) corticosteroids and analgesics (eg Fentary) . To determine the effects of vehicles (eg DMSO) on penetration of drugs in the horse . To determine the effects of skin damage (eg rashes) and altered microenvironment (eg bandages saddles) on transdermal drug movement in the horse