Towards more effective laryngeal reinnervation in horses.

The University of Melbourne

  • Project code: PRJ-000242

  • Project stage: Closed

  • Project start date: Tuesday, May 1, 2007

  • Project completion date: Wednesday, February 25, 2009

  • National Priority: HOR-Thoroughbred diseases and parasites


Thoroughbred Horses

Research Organisation

The University of Melbourne

Objective Summary

– to evaluate key markers of regenerative capacity and reinnervation (N-CAM expression endplates and satellite cells). – to use these markers together with evaluation of return towards normal fibre type (specifically the MyHC isoform distribution) andstandard clinical techniques to measure the rate of reinnervation of the cricoarytenoideus muscle (CAD) in 2 horses with RLN treated with an established NMP technique employing the novel application of neurotrophins. – determine whether this treatment has the potential to result in sufficient reinnervation to allow horses to resume race training at 12 weeks and full race training by 6 months warranting a larger clinical trial.